RA/Sr. RA

Prellis Biologics uses proprietary technology to 3D print lymph node organoids, which we are using to generate in vitro antibody libraries andinvitrohumanlymphnodecoculturesfor generating antigen-specific B-cells.We are seeking a Research Associate – Senior Research Associate, Antibody Screening and Characterization to join our Antibody Screening team.This role will report to the Scientist heading antibody screening, with accountability for supporting small-scale protein purification and high-throughput antibody screening and characterization efforts, particularly using SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) technologies.

Key Responsibilities:

• Perform high-throughput small-scale protein purification and QC/analytics protocols, including SDS-PAGE, affinity chromatography and size-exclusion chromatography, to obtain highly pure antibody preparations.
• Support high-throughput antibody screening and characterization using BLI and SPR technologies to assess binding kinetics, specificity, and affinity, to support multiple antibody discovery projects.
• Independently troubleshoot and contribute to protocol optimization for enhanced efficiency and increased throughput.
• Collaborate with cross-functional teams, providing technical support for various projects requiring automated workflows.
• Maintain accurate records of experiments, analyze data, and present results in team meetings.
• Qualifications
• B.S in Molecular Biology, Chemistry, Immunology, Biotechnology, or related life science field with 4+ years of experience, or M.S. with 2+ years of relevant experience.
• Strong proficiency in antibody screening and characterization workflows, including protein quantification, purification, and characterization methods.
• Hands-on experience in small-scale protein purification using chromatography resins and antibody screening using BLI technique, such as Octet®. Familiarity with Carterra® LSA/LSAXT SPR is a strong plus.
• Ideal candidates will have prior experience in single B-cell antibody discovery workflows with an end goal of identifying novel therapeutic candidates.
• Strong organizational and time management skills to contribute to multiple projects in a fast-paced environment
• Excellent communication skills and ability to document and present experimental results.
• Experience with liquid-handling robots and other automation equipment is a strong plus.