Senior Research Associate/Associate Scientist, Antibody Screening and Display

The Opportunity

Prellis Biologics uses a combination of novel, cutting edge methods in machine learning, biology at scale and next gen antibody discovery that address key bottlenecks in the drug development pipeline. To accomplish that, we are putting together an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem. 

We are seeking a Senior Research Associate –Associate Scientist, Antibody Screening and Display to join our Antibody Screening team.This role will report to the Sr. Scientist heading antibody screening and display, with accountability for supporting mammalian cell culture, high-throughput flow cytometry, and transient transfections.

Key Responsibilities:

• Execute high-throughput small-scale protein expression and flow cytometry workflows to characterize antibody samples.
• Support antibody screening programs by expressing antibodies in mammalian cells in high-throughput, thenstaining cell surface markers with high-throughput flow cytometry.
• Analyze, interpret, and present expression and flow data to inform antibody selection and optimization decisions.
• Independently troubleshoot and optimize experimental protocols for improved throughput, accuracy, and reproducibility.
• Maintain meticulous experimental records in electronic lab notebooks and effectively communicate findings in internal meetings.

Qualifications:

• B.S in Molecular Biology, Biochemistry, or related life science field with 5+ years of experience, or M.S. with 3+ years of relevant experience.
• 3+ years hands-on experience with flow cytometry is required.
• Proficient in mammalian cell culture of adherent and suspension immortalized cell lines, Expi293, HEK293T.
• Proficient in transient transfections of immortalized cell lines.
• Ideal candidates will have prior experience supporting high-throughput antibody discovery workflows with an end goal of identifying novel therapeutic candidates.
• Strong organizational and time management skills to contribute to multiple projects in a fast-paced environment.
• Experience with electronic lab notebooks (Benchling).
• Excellent communication skills and ability to document and present experimental results.

Nice-To-Haves:

• Experience with automation platforms (liquid handlers) is a strong plus.
• Experience with Illumina Next-Generation Sequencing, or 10X sequencing is a strong-plus.
• Experience with high-throughput protein purification, Cytiva AKTA, Agilent HPLC, Octet BLI, and/or Carterra SPR is a plus.
• Experience with display workflows in mammalian cells, yeast, or phage is a plus.

Join Our Team

About Prellis Biologics

At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before. Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Prellis offers compelling benefits based on eligibility, work/life balance, and career development opportunities.

Application deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.