Sr. Associate Scientitst -Cell Culture and Reagent Development

Position Overview:

Prellis Biologics uses proprietary technology to 3D print lymph node organoids, which we are using for generating antigen-specific B-cells and ultimately in vitro antibody libraries for multiple targets. We are seeking a highly motivated Senior Associate Scientist with a strong background in cellular biology to join our team on a contract basis. In this role, the individual will be supporting our ex vivo antibody production efforts as well development for the generation of detection reagents for flow cytometry. The ideal candidate will have a strong background in cell biology, biomolecular techniques, and experience in flow cytometry and production environments.

Primary Responsibilities:

• Routinely utilize standardized cell culture methods to elicit antigen-specific B cells.
• Independently perform single cell sorting for downstream analysis following detailed work instructions.
• Routinely synthesize flow cytometry detection reagents, including but not limited to biotinylated proteins, streptavidin tetramers, and fluorescently labeled proteins
• Utilize a broad suite of biomolecular and biochemical assays including flow cytometry, SDS-PAGE, Mass spectroscopy, and UV-Vis to characterize the reagents
• Troubleshoot biotinylation or tetramer generation as needed, optimize the workflow for degree of labeling as well as on-cell detection using flow cytometry
• Maintain detailed, accurate, and timely documentation of all experiments in electronic lab notebooks (ELN)
• Collaborate closely with cross-functional teams to support project goals
• Contribute to data interpretation and troubleshooting efforts as needed

Required Qualifications:

• B.S. or M.S. in Cell Biology, Molecular Biology, Biochemistry, Chemistry, Biomedical Engineering, or a related field with 3+ years of experience of hands-on laboratory work (industry experience strongly preferred)
• Demonstrated experience in mammalian cell culture, flow cytometry, and bioanalytical assays such as SDS-PAGE, UV-Vis
• Comfortable working with LIMS/ELN systems such as Benchling
• Demonstrated ability to work independently in a laboratory setting
• Strong organizational skills and excellent attention to detail
• Effective written and verbal communication skills
• Ability to work well both independently and in a collaborative, team-oriented environment
• Proactive, collaborative, and adaptable in a dynamic research setting.

Preferred Experience:

• Working knowledge of immunology and biochemistry
• Flow cytometry techniques and bead-based assays for reagent QC

About Prellis Biologics

At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before.Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Application deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.