Sr. Lab Technician

Sr. Lab Technician

Prellis Biologics is a seeking a Sr. Lab Technician to drive the research and development of proprietary EXIS (External Immune System) technology and associated production infrastructure. The Sr. Lab Technician will be responsible for maintaining the preparation, disposition, and aliquoting of critical reagents as well as bulk isolating PBMCs and critical cell types for all incoming human donors.

Responsibilities:

Expected to work in a pre-manufacturing environment and have a basic understanding of traceability, good manufacturing practices (GMP), and standard operating procedures (SOPs)/work instructions (WIs).

Ability to follow SOPs and WIs as written and record the necessary information in a batch record stored in an electronic lab notebook

Aseptically prepare sterile cell culture media, reagents, and buffers needed for critical workflows

Bulk isolate PBMCs from Leukopaks and continue cell separation into specific cell types with automated cell separation machines (i.e. MultiMACS and RoboSep)

Batch cryopreserve PBMCs and critical cell types and maintain liquid nitrogen inventory

Recommend changes to improve production processes, equipment, product quality/yield, and supports the development of DOE-type studies and methodologies for measuring and verifying the impact of changes.

Use a risk-based approach to implement changes and understand implications of changes on downstream processes and users.

Works cross-functionally with end-users (cell biologists, immunologists, engineering groups) to adequately capture process requirements.

Maintain and report inventory on critical reagents and perform regular checks to dispose of any expired reagents.

Execute validation testing for key company metrology.

Help manage and catalog Material Safety Data Sheets (MSDSs) in collaboration with the operations and engineering departments.

Education and Experience Requirements:

Minimum of AA, certificate program, comparable training, or higher with 10+ years of experience in hands-on wet lab techniques for manufacturing, cell separation techniques, and disposition and labeling of critical reagents

Proficiency in using Microsoft Office applications and SharePoint is required.

Understanding of quality systems as they relate to production operations is required.

Ideal candidates will have prior experience working with ELNs (Electronic Lab Notebooks)

Ideal candidates will have some prior experience with mammalian cell culture techniques, flow cytometry, single B cell antibody workflows, and protein/particle formulation and analysis techniques.

About Prellis Biologics
At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before. Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.

What you can expect of us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
The expected annual salary range for this role in the U.S. is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Application deadline
Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.