Sr. Research Associate - Antibody Purification

The heart of Prellis Bio’s strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and next gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications. To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

• Position Overview:
  Seeking a Research Associate/ Associate Scientist/ Scientist to join our team focused on small-scale expression & purification of antibodies for assay applications. The role uses recombinant expression platforms and requires experience in Protein A workflows, laboratory automation, and electronic recordkeeping.

Key Responsibilities:

•Perform small-scale Expi293 transient expressions.

•Support automated expression and harvest workflows.

•Execute small-scale purification workflows for antibodies, fusion proteins, and bispecifics.

•Purify proteins using Protein A/G, IEX, and SEC methods.

•Conduct buffer exchange, desalting, and concentration.

•Operate KingFisher systems; ÄKTA experience preferred.

•Use Lunatic, KingFisher, and other automation tools for high-throughput workflows.

•Implement and optimize small-scale automated protocols.

•Run SDS-PAGE and LabChip assays for protein quality.

•Maintain accurate ELN documentation.

•Communicate results and support cross-team workflows.

Qualifications:

• BS, MS, or PhD degree in life sciences (e.g., biochemistry, molecular biology).
• Minimum 3 years of relevant industry experience in antibody purification or protein biochemistry.
• Strong experience in purification of antibodies, fusion proteins, and/or bispecifics.
• Hands-on experience with buffer exchange, desalting, and protein concentration methods.
• Proficiency in SDS-PAGE and common protein analytics.
• Experience with Lunatic, KingFisher, and ÄKTA systems (preferred).
• Experience with Expi293 small-scale transient expression.
• Demonstrated experience with small-scale automation in protein expression or purification workflows.

About Prellis Biologics

At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before.Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Application deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.