Sr. Scientist-Antibody Analytical Characterization

Senior Scientist – Antibody Analytical Characterization (Mass Spectrometry)

The heart of Prellis Bio’s strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and next gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications. To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

We are looking for an accomplished and detail-oriented Senior Scientist with strong expertise in mass spectrometry (MS) and aggregation analysis to join our Antibody Engineering team. This individual will lead the design and execution of analytical strategies focused on the biophysical characterization of therapeutic antibodies, emphasizing mass spectrometry and analytical size-exclusion chromatography (aSEC).

Key Responsibilities

• Lead mass spectrometry-based characterization of therapeutic proteins including monoclonal antibodies, bispecifics, and antigens:
• Perform intact mass and subunit analysis
• Execute peptide mapping and sequence confirmation
• Profile post-translational modifications (e.g., glycosylation, oxidation, deamidation)
• Develop, optimize, and troubleshoot aSEC methods to assess aggregation, purity, and product quality.
• Characterize high molecular weight aggregates, fragments, and other product- or process-related impurities.
• Collaborate closely with Antibody Discovery, Immunogen Design, and Target Biology teams to integrate analytical insights into therapeutic development.
• Prepare high-quality technical documentation, including protocols, reports, and SOPs.

Qualifications

• Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related discipline with 3+ years of relevant industry experience;
  – or M.S. with 8+ years,
  – or B.S. with 10+ years in biopharmaceutical analytical development.
• Proven hands-on expertise in LC-MS/MS, intact mass analysis, peptide mapping, and PTM characterization of antibody-based therapeutics.
• Strong experience with aSEC for aggregation analysis, including method development and troubleshooting.
• Familiarity with additional chromatographic techniques such as RP-HPLC, HIC, and IEX.
• Solid skills in data analysis, interpretation, and scientific communication (both written and verbal).

About Prellis Biologics

At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before.Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Prellis offers compelling benefits based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A competitive employee benefits package, including group medical, dental and vision coverage, life and disability insurance, flexible spending accounts an a 401(k) plan
• Stock-based long term incentives
• Bonus plan
• Holiday package including a 1+ week winter shutdown
• Flexible work models, including remote and hybrid working arrangements, where possible

Application deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.